Remember that ModOrganizer uses basically a virtual file system, so the game files aren't altered. This means when using it to manage the game's mods you need to launch any other modding related programs through it, including NVSE. NVSE as an example.

Next to the 'Run' button is a drop-down-list-box. This will let you choose what programs to run or edit/add/remove programs in the list. You will need to add NVSE there if it isn't already, then once added select it from the list before clicking 'Run'. Whatever option is selected in that list is what will be launched, and will see the modded version of the game thanks to the virtual file system approach. SwordedGun: Hi, I have a problem with nvse and mod organizer. I install the mods through mod organizer no problem and all but the thing is whenever I launch New Vegas through it, it launches with the mods installed but not with script extender for some reason and when I try to launch the NVSE instead no mods are being launched with it.

I read somewhere it causes problems if fallout 4 and/or mod organizer is located in the windows 'program files' folders because of the security settings of modern windows versions. Try to move mod organizer to a different folder outside of os folders.

I played it a couple of months back on the first version of MO and it worked fine, I even tried using that version again but it didn't work. You do not install NVSE in Mod Organizer. You install it in the FONV Main folder ONLY. Unpack NVSE and install the files in your main Fallout New Vegas folder where ever you have it installed. The game and mods run NVSE through the drop down menu on Mod Organizer.

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Simply go up to the Gears Icon on the upper left. Click it and go to Title.

Title it NVSE and then where it says start from simply look for the NVSE Loader.exe in your FONV main folder and click on it. It adds NVSE to the upper right drop down menu on Mod Organizer - right next to the RUN Button. Now you are all set up.